cGAS activation in phased droplets
نویسندگان
چکیده
منابع مشابه
Activation of cGAS-dependent antiviral responses by DNA intercalating agents
Acridine dyes, including proflavine and acriflavine, were commonly used as antiseptics before the advent of penicillins in the mid-1940s. While their mode of action on pathogens was originally attributed to their DNA intercalating activity, work in the early 1970s suggested involvement of the host immune responses, characterized by induction of interferon (IFN)-like activities through an unknow...
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Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease 7 (SENP7) interacted with and potentiated cGAS activation. The small ubiquiti...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2018
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-018-0087-6